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NOVEMBER 14, 2025

A Novel Gene Therapy for Bacillus Calmette-Guérin–Unresponsive Non–Muscle-Invasive Bladder Cancer

ADSTILADRIN®(nadofaragene firadenovec-vncg) is the first and only FDA-approved intravesical non-replicating gene therapy for high-risk Bacillus Calmette-Guérin–unresponsive non–muscle-invasive bladder cancer. This monograph reviews the role of ADSTILADRIN in the evolving treatment landscape, its efficacy and safety profile, and practical considerations for implementation in clinical practice.

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