Originally published by our sister publication Pain Medicine News
By Myles Starr
Data from a new study indicate that an immunoconjugate vaccine reduces the antinociceptive, behavioral and physiologic effects of fentanyl, in experimental rats.
The vaccine is composed of a fentanyl-like hapten that includes a linker with a carboxyl moiety suitable for carbodiimide coupling chemistry in order to create amide bonds with lysine residues on the carrier protein CRM197—a genetically deactivated