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JULY 8, 2021

Metoclopramide Plus Diphenhydramine Effective in Headache Following Trauma

By David C. Holzman

Originally published by our sister publication, Pain Medicine News

In cases of post-traumatic headache, metoclopramide plus diphenhydramine provided superior relief to placebo, according to new research.

“Our primary hypothesis is that metoclopramide plus diphenhydramine (Benadryl, Johnson & Johnson) would improve headache more than placebo one hour after medication administration, as measured on a validated 0-10 pain scale,” the investigators wrote.