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MAY 29, 2025

CDC Updates Nonoccupational Post-Exposure Prophylaxis HIV Recommendations


Originally published by our sister publication Infectious Disease Special Edition

By Ethan Covey

The CDC has issued updated recommendations for antiretroviral post-exposure prophylaxis (PEP) for nonoccupational exposure to HIV (MMWR Recomm Rep 2025;74[1]:1-56).

“Tens of thousands of people in the U.S. acquire HIV annually, even though it is preventable through various interventions like PEP,” said author Katrina Byrd, MD, a medical epidemiologist with the National Center for HIV, Viral