The Resurgence of the Tetracyclines

A Supplement to Introduction In the United States, more than 2.9 million peo.ple experience an infection from antibiotic-resistant bacteria each year; moreover, at least 35,000 deaths are a direct consequence of these infections.1 Antibi.otic resistance continues to spread through new bac.terial forms, with some resistant to multiple classes of antibiotics, making it a serious global threat.1,2 As one of the longstanding drug classes for the treat.ment of bacterial infections, tetracyclines