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APRIL 24, 2025

Ensitrelvir Reduces COVID-19 Risk by 67%

By Marie Rosenthal, MS

Ensitrelvir, an antiviral being developed to prevent COVID-19, reduced the risk of developing the infection by 67% in uninfected people after exposure to SARS-CoV-2 compared with placebo at day 10, according to results presented at CROI 2025, held in San Francisco (abstract 200).

The 67% reduction is “super exciting,” said Diane Havlir, MD, the CROI chair, and the chief of the HIV, Infectious Diseases and Global Medicine Division at Zuckerberg San Francisco