Stopping vasopressin before norepinephrine in shock patients is associated with a higher incidence of hypotension, according to a new retrospective study from investigators at Mayo Clinic (Sci Rep 2021;11[1]:16680).
The 2021 Surviving Sepsis Campaign guidelines (Crit Care Med 2021;49[11]:e1063-e1143) recommend norepinephrine as the first-line vasopressor of choice in adults with septic shock, with vasopressin as a second-line adjunct in patients for whom high doses of norepinephrine