Women with breast cancer who have a particular genetic biomarker are at increased risk for anthracycline-induced congestive heart failure (CHF), according to the results of a genome-wide association study.
In this study, the investigators identified the single nucleotide polymorphisms associated with an increased risk for anthracycline-induced CHF among the 3,431 patients enrolled in the randomized, Phase III Eastern Cooperative Oncology Group (ECOG) 5103 clinical trial (Clin Cancer Res