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APRIL 27, 2016

FDA Approves Cabometyx for Advanced RCC

 
The FDA approved cabozantinib (Cabometyx, Exelixis) to treat advanced renal cell carcinoma (RCC) in patients who have received prior antiangiogenic therapy.
 
Most clear cell RCC tumors have lower-than-normal levels or function of the von Hippel-Lindau protein, which leads to higher levels of MET signaling protein, a single-pass tyrosine kinase receptor; AXL gene; and vascular endothelial growth factor (VEGF). Higher-than-normal levels of these proteins can promote