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MARCH 16, 2022

Adding Palbociclib to Endocrine Therapy Shows No Benefit in Study

Originally published by our sister publication, Clinical Oncology News.

By Kate O’Rourke

There is no benefit to adding palbociclib to endocrine therapy in patients with early hormone receptor (HR)-positive, HER2-negative breast cancer, according to final results from the phase 3 PALLAS trial.

The results are surprising because cyclin-dependent kinase (CDK) 4/6 inhibitors combined with endocrine therapy is the standard of care for advanced breast cancer.

PALLAS (Palbociclib Collaborative