IP0864- Neuromuscular Block: Challenges in Clinical Practice - The purpose of this activity is to provide information to anesthesiologists and other interested practitioners on challenges associated with neuromuscular block that can be encountered during procedures, including selection of an appropriate neuromuscular blocking agent (NMBA), rapid sequence induction, monitoring, and reversal of neuromuscular block. The need for this activity was determined through input from Core’s past participants as well as literature and research review that indicated the information should be available to a wider audience and through additional CME delivery methods.

SR0923- Evaluating the Efficacy, Immunogenicity, and Safety of Topical Thrombins in Surgery - Minimal blood loss is a hallmark of successful surgery. Despite the availability of common techniques, such as suture ligation, electrocautery, and simple pressure, bleeding continues to be a challenge during surgery. In these cases, topical hemostatic adjuncts are frequently employed to promote coagulation and achieve hemostasis. Topical thrombins from 3 distinct biologic origins—bovine, human plasma–derived, and recombinant human—make up one group of agents used to achieve hemostasis when standard surgical techniques have proven ineffective. Evidence from recently published clinical trials regarding the relative efficacy, immunogenicity, and safety of these 3 agents is timely and appropriate for clinicians managing outcomes and improving patient care during surgery.

SR0862 - Recent Advances in Biologic Hemostatic Agents - Despite the advances made to reduce postoperative complications, blood loss remains a significant problem and can lead to morbidity and mortality. Traditional surgical techniques (eg, cautery and suture ligation) may not adequately control bleeding, or it may not be possible to use them during certain surgical procedures. During the past few decades, biologic hemostatic agents that mimic and enhance stages of the coagulation cascade have emerged. This special report discusses these agents, which can be categorized as systemic and topical agents.

SR0953 - Emerging Parenteral Therapies for Multimodal Postoperative Analgesia - Combining analgesics with different mechanisms of action aids the patient in the perioperative setting by targeting more than one pain pathway; this provides additional analgesia and perhaps synergistic pain-relieving effects. A multimodal approach to postoperative pain would provide effective analgesia, reduce opioid-related side effects, and improve clinical outcomes, such as length of hospital stay, morbidity, and mortality. However, the optimal combination of analgesics, dosages, and timing of administration to achieve these outcomes are not known. This monograph outlines the current parenteral treatment options and strategies available for the management of postoperative pain.